Article(electronic)#1May 24, 2022
Educación in Our Own Terms: Survivance Amongst Latinx Migrant and Seasonal Farmworkers in K-12 Schools and Beyond
In: Journal of Latinos and education: JLE, Volume 22, Issue 5, p. 1991-2007
ISSN: 1532-771X
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Article(electronic)#22021
Self-efficacy and commitment as psychological resources to adherence to walking despite chronic pain. A study on women with fibromyalgia
In: Ansiedad y Estrés: una revista multidisciplinar de psicología, medicina, neurociencias y ciencias sociales = Anxiety & stress : a multidisciplinary journal of psychology, medicine, neurosciences and social sciences, Volume 28, Issue 3, p. 179-185
ISSN: 2174-0437
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Open Access#32020
ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans
Boekstegers, Félix; Marcelain Cubillos, Katherine; Barahona Ponce, Carol; Báez Benavides, Pablo F; Müller, Bettina; Toro, Gonzalo de; Retamales, Javier; Barajas Barajas, Olga
Boekstegers, Félix; Marcelain Cubillos, Katherine; Barahona Ponce, Carol; Báez Benavides, Pablo F; Müller, Bettina; Toro, Gonzalo de; Retamales, Javier; Barajas Barajas, Olga; Ahumada Olea, Mónica; Morales, Erik; Rojas, Armando; Sanhueza, Verónica; Loader, Denisse; Rivera, María Teresa; Gutiérrez, Lorena; Bernal, Giuliano; Ortega, Alejandro; Montalvo, Domingo; Portiño, Sergio; Bertrán, María Enriqueta; Gabler, Fernando; Spencer, Loreto; Olloquequi, Jordi; González Silos, Rosa; Fischer, Christine; Scherer, Dominique; Jenab, Mazda; Aleksandrova, Krasimira; Katzke, Verena; Weiderpass, Elisabete; Moradi, Tahereh; Fischer, Krista; Bossers, Willem; Brenner, Hermann; Hveem, Kristian; Eklund, Niina; Völker, Uwe; Waldenberger, Melanie; Fuentes Guajardo, Macarena; González-José, Rolando; Bedoya, Gabriel; Bortolini, María C; Canizales, Samuel; Gallo, Carla; Ruiz Linares, Andrés; Rothhammer, Francisco; Bermejo, Justo Lorenzo
Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs. ; Federal Ministry of Education & Research (BMBF) 01DN15021 European Union (FP7 Research infrastructures) within the initiative "Biobanking and Biomolecular Research Infrastructure -Large Prospective Cohorts" (Collaborative study "Identification of biomarkers for gallbladder cancer risk prediction Towards personali Germany's Excellence Initiative of Heidelberg University within the program "Mobilitaetsmassnahmen im Rahmen internationaler Forschungskooperationen 2015-16" support program "Stiftungen und Preise" of the Ruprecht-Karls-Universitaet Heidelberg German Research Foundation (DFG) LO 2061/1 Biobank of University of Chile
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