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AbstractDrawing from case studies from the Estonian biotechnology sector, we demonstrate that a focus on the classic formal approach to technology transfer does not fully capture the dynamics and challenges of technology transfer in a peripheral context. We focus on biotechnology because this is an area where entrepreneurial orientation of knowledge institutions and formal models of technology transfer are highly visible. Our case studies show that the knowledge generation and the diffusion contexts of peripheral economies can create barriers to technology transfer that conventional policy approaches do not address.

Empirical studies have shown that the internationalization processes of firms in re-search and development (R&D) are slower compared to those of trade or investments. The pioneers of R&D internationalization have been high-tech companies in small mar-kets with little research resources in their home countries. The motives for internation-alization in R&D besides widening the R&D resource base concern the search for the novelty value of collaboration for innovation, but the costs are associated with collab-orative capacity and lack of experience. EU has aimed at boosting Europe's industrial leadership and competitiveness via different policy instruments, mainly R&D subsidies to SMEs and larger firms for collaborative partnerships with various institutional and geographical scopes. By comparing FP7 and Horizon2020, two recent Framework Pro-grammes (FPs), the innovation focus has strengthened besides basic research within subsidized R&D activities. Additionally, the projects involve more partnerships between higher education and research institutions, private firms and public sector bodies. The picture of the network formed by supported projects shows a concentration around larger and older EU member states while the smaller countries, but also EU13 (the new member states) locating on the periphery. Individual countries are engaged in international R&D networks with different patterns, but for EU13 countries the network-ing barriers seem to be higher, even in the most successful cases the single partner (mostly SME) projects dominate. In gaining stronger hub roles in the private firm R&D networks, the economies in all countries need to improve connectivity within and out-side their communities.