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AbstractBackgroundGirls with a mild intellectual disability generally receive less sexuality education than their non‐disabled peers, while their needs for sexual knowledge are possibly greater. This study aimed to evaluate the effect and process of a new sexuality education programme (Girls' Talk+), focused on sexual health among girls with a mild intellectual disability in the Netherlands.MethodsA mixed methods approach was applied, using participant questionnaires (n = 249), logs written by trainers (n = 17) and interviews with trainers (n = 10). Descriptive statistics and linear regression models were used to analyse the quantitative data. Several coding phases were used to analyse the interviews.Results and conclusionsThis study provides some indication that Girls' Talk+ has positive results on improving knowledge, attitude, and self‐efficacy in relation to sexual health as well as trainer and participant satisfaction with the programme.