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Man spends the greater portion of his life in sub-optimum states of consciousness. The paper reviews the experimental literature describing normal human performance at different levels of drowsiness and sleep, as these states are defined by electroencephalographic patterns. Among the types of behavioral responses to stimuli discussed are reflexes, simple movements, detection (i.e. arousal to external stimuli and awareness of internal states), discrimination, learning, and recall. Non-behavioral electroencephalographic responses are also described. Suggestions are made for future research.

Active shooter incidents represent an increasing threat to American society, especially in commercial and educational buildings. In recent years, a wide variety of security countermeasures have been recommended by public and governmental agencies. Many of these countermeasures are aimed to increase building security, yet their impact on human behavior when an active shooter incident occurs remains underexplored. To fill this research gap, we conducted virtual experiments to evaluate the impact of countermeasures on human behavior during active shooter incidents. A total of 162 office workers and middle/high school teachers were recruited to respond to an active shooter incident in virtual office and school buildings with or without the implementation of multiple countermeasures. The experiment results showed countermeasures significantly influenced participants' response time and decisions (e.g., run, hide, fight). Participants' responses and perceptions of the active shooter incident were also contingent on their daily roles, as well as building and social contexts. Teachers had more concerns for occupants' safety than office workers. Moreover, teachers had more positive perceptions of occupants in the school, whereas office workers had more positive perceptions of occupants in the office.

This article focuses on how the categories of 'normal' and 'extreme' in the context of work might be renegotiated through the development of human enhancement technologies which aim to enable the human body to be pushed beyond its biological limits. The ethical dimensions of human enhancement technologies have been widely considered, but there has been little debate about their role in the broader world of employment—nor, conversely, the recognition that prevailing employment relationships might shape the development and uptake of such technologies. Addressing the organisation of work within 'advanced' capitalist economies, this article considers the arguments for the potential use of cognitive enhancers, so-called 'smart drugs', in various domains of work such as surgery and transportation. We argue that the development of human enhancement technologies might foster the normalisation of 'working extremely'—enabling longer working hours, greater effort or increased concentration—and yet at the same time promote the conditions of possibility under which workers are able to work on themselves so as to go beyond the norm, becoming 'extreme workers'. Looking at human enhancement technologies not only enables us to see how they might facilitate ever greater possibilities for working extremely but also helps us to understand the conditions under which cultures of extreme work become the norm and how workers them/ourselves accept or even embrace such work.

This paper identifies the mechanism by which patients with multiple sclerosis develop secondary autoimmunity after treatment with the lymphocyte-depleting humanized monoclonal antibody alemtuzumab (Campath-1H). In identifying this mechanism, it shows that T-cell homeostatic proliferation can lead to autoimmunity in humans. Alemtuzumab is one of the most effective treatments of multiple sclerosis tested to date; it is currently licensed in the European Union and under consideration by the Food and Drug Administration. Understanding what drives its most significant side effect is of clear clinical importance.

AbstractA previous study on key farm performance indicators for animal welfare incidents in Ireland provided anecdotal evidence to suggest that farm animal welfare standards are often underpinned by social and human health‐related factors among farmers. The present study took an exploratory approach to identify these factors and how they influence farm animal neglect. Semi‐structured interviews were conducted with farmers. Identified factors included farming difficulties associated with age and help on the farm (n = 5), mental health‐related problems (n = 4), and differing perceptions of animal welfare (n = 4). Stress was a prevalent theme. Evidence suggests that these negative human factors impact on farmers' ability to carry out farm management activities. Poor uptake of support services was noted and barriers included resistance, self‐reliance and an inability to talk openly about mental health problems. Initiatives such as the early warning system, aimed at reducing the incidence of farm animal neglect in Ireland, should be understood as often involving a human element. In particular, further research is required into how mental health problems may lead to altered or reduced regard for animal welfare.