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Seasonal variations are rarely considered a contributing component to human tissue function or health, although many diseases and physiological process display annual periodicities. Here we find more than 4,000 protein-coding mRNAs in white blood cells and adipose tissue to have seasonal expression profiles, with inverted patterns observed between Europe and Oceania. We also find the cellular composition of blood to vary by season, and these changes, which differ between the United Kingdom and The Gambia, could explain the gene expression periodicity. With regards to tissue function, the immune system has a profound pro-inflammatory transcriptomic profile during European winter, with increased levels of soluble IL-6 receptor and C-reactive protein, risk biomarkers for cardiovascular, psychiatric and autoimmune diseases that have peak incidences in winter. Circannual rhythms thus require further exploration as contributors to various aspects of human physiology and disease. ; The Gambian study providing data for analysis was supported by core funding MC-A760-5QX00 to the International Nutrition Group by the UK Medical Research Council (MRC) and the UK Department for the International Development (DFID) under the MRC/DFID Concordat agreement. This work was supported by the JDRF UK Centre for Diabetes-Genes, Autoimmunity and Prevention (D-GAP; 4-2007-1003), the JDRF (9-2011-253), the Wellcome Trust (WT061858/091157), the National Institute for Health Research Cambridge Biomedical Research Centre (CBRC) and the Medical Research Council (MRC) Cusrow Wadia Fund. The research leading to these results has received funding from the European Union's 7th Framework Programme (FP7/2007–2013) under grant agreement no.241447 (NAIMIT). The Cambridge Institute for Medical Research (CIMR) is in receipt of a Wellcome Trust Strategic Award (WT100140). X.C.D. was a University of Cambridge/Wellcome Trust Infection and Immunity PhD student. R.C.F. is funded by a JDRF post-doctoral fellowship (3-2011-374). C.W. and H.G are funded by ...

Dieses Positionspapier basiert auf der langjährigen klinischen Erfahrung und grundlagen-wissenschaftlichen Forschung der Autoren zur Diagnose und Behandlung von Kindern und Jugendlichen mit einem präsymptomatischen Frühstadium des Typ-1-Diabetes. Der Nutzen sowie potenzielle Nachteile der Früherkennung von Typ-1-Diabetes durch ein Inselautoantikörper-Screening werden kritisch diskutiert. Zudem werden die Perspektiven einer Verzögerung des Ausbruchs der klinischen Stoffwechselerkrankung durch eine Teplizumab-Behandlung adressiert. Wir sehen heute die Chance einer relevanten Verbesserung der therapeutischen Möglichkeiten und der Lebensperspektive betroffener Kinder und Jugendlicher. Wichtige nächste Schritte für die Implementierung eines Inselautoantikörper-Screenings in Deutschland sind die Fortbildung der Kinder- und Jugendärzte, die über das Screening aufklären sollen, die Etablierung von wenigen überregionalen Laboratorien, die die Testung durchführen, und die Ausweitung regionaler Kapazitäten für Schulung und Betreuung der Kinder mit einem Frühstadium des Typ-1-Diabetes.

This position paper is based on the authors' many years of clinical experience and basic science research on the diagnosis and treatment of children and adolescents with a presymptomatic early stage of type 1 diabetes. The benefits as well as potential disadvantages of early detection of type 1 diabetes by islet autoantibody screening are critically discussed. In addition, the perspectives of delaying the onset of the clinical metabolic disease through treatment with teplizumab are addressed. Today, we see the chance of a relevant improvement in the therapeutic options and life perspectives of affected children and adolescents. Important next steps for the implementation of islet autoantibody screening in Germany are the training of pediatricians who should inform families about the screening, the establishment of a few transregional laboratories that carry out the test, and the expansion of regional capacities for the training and care of children with an early stage of type 1 diabetes.