Suchergebnisse

This paper focuses on the administrative acts issued by the Autonomous Municipal Government of Azogues Canton, during the year 2020. It is verified here, to what extent the administrative acts comply with the essential requirement of motivating their acts, as a universal and constitutional guarantee of the right to defense. Thus, the pertinent parameters were established and relevant aspects of the motivation of administrative acts were analyzed from a historical, conceptual, dogmatic, constitutional, legal and jurisprudential point of view, as a theoretical framework and state of the art. The research used a scientific approach and a qualitative methodology (case by case), based on a sample of 75% of the administrative acts issued during the year in question. Finally, conclusions and recommendations were drawn for the municipal entity to optimize the motivation of its acts, considering that they could be useful for all public sector institutions. ; El presente trabajo apunta hacia los actos administrativos emitidos por el Gobierno Autónomo Municipal del Cantón Azogues, durante el año 2020. Se verifica aquí, en qué medida el actuar administrativo cumple con el requisito imprescindible de motivar sus actos, como garantía universal y constitucional del derecho a la defensa. Así, se establecieron los parámetros pertinentes y se analizaron aspectos relevantes sobre la motivación de los Actos Administrativos desde un punto de vista histórico, conceptual, dogmático, constitucional, legal y jurisprudencial, a manera de marco teórico y estado del arte. La investigación realizó un abordaje científico y se utilizó la metodología cualitativa (caso por caso), tomando como base una muestra del 75% de los actos administrativos emitidos durante el año referido. Finalmente, se realizaron conclusiones y recomendaciones para que la entidad municipal optimice la motivación de sus actos, contando con que las mismas podrán servir para todas las instituciones del sector público.

Debido a la inexistente recopilación bibliográfica sobre el tocino artesanal azuayo y su casi extinta utilización en la actualidad, la presente publicación tiene como objetivo realizar un estudio comparativo de las cualidades organolépticas entre el tocino tradicional y su contraste con el tocino industrial aplicado en elaboraciones típicas de la gastronomía de la provincia. Para el desarrollo de este trabajo se aplicaron encuestas y entrevistas estratificadas a personas de la ruralidad del Azuay, para conocer de primera mano el proceso de elaboración del tocino artesanal; posteriormente se realizó un análisis comparativo de las características organolépticas de los dos productos. Finalmente se validó la propuesta ante un grupo extenso conformado por vendedores de expendios de comida típica del mercado 27 de febrero y expertos en el área gastronómica. Como resultado se evidencia la diferencia significativa en la mayoría de los atributos y se concluye con la preferencia del producto artesanal.

Altres ajuts: NM-M was supported by the Spanish Association Against Cancer (AECC), AECC JP Vizcaya. VT is supported by Fundación Vasca de Innovación e Investigación Sanitarias, BIOEF (BIO15/CA/052), the department of health of the Basque Government (2016111109) and the 2016 grant of the AECC (Junta provincial de Bizkaia). LA, AA-A and LV-J were supported by the Basque Government of education. The work of A.C. is supported by the Ramón y Cajal award, the Basque Department of Industry, Tourism and Trade (Etortek) and the department of education (IKERTALDE IT1106-16), FERO VIII Fellowship, the BBVA foundation, Severo Ochoa. Excellence Accreditation SEV-2016-0644) and the European Research Council (Starting Grant 336343; Proof of Concept 754627). The participation of AC, VT, NM-M, SF and AZ as part of CIBERONC was co-funded with FEDER funds. ; Prostate cancer is diagnosed late in life, when co-morbidities are frequent. Among them, hypertension, hypercholesterolemia, diabetes or metabolic syndrome exhibit an elevated incidence. In turn, prostate cancer patients frequently undergo chronic pharmacological treatments that could alter disease initiation, progression and therapy response. Here we show that treatment with anti-cholesterolemic drugs, statins, at doses achieved in patients, enhance the pro-tumorigenic activity of obesogenic diets. In addition, the use of a mouse model of prostate cancer and human prostate cancer xenografts revealed that in vivo simvastatin administration alone increases prostate cancer aggressiveness. In vitro cell line systems supported the notion that this phenomenon occurs, at least in part, through the direct action on cancer cells of low doses of statins, in range of what is observed in human plasma. In sum, our results reveal a prostate cancer experimental system where statins exhibit an undesirable effect, and warrant further research to address the relevance and implications of this observation in human prostate cancer.

Lyme carditis is an extracutaneous manifestation of Lyme disease characterized by episodes of atrioventricular block of varying degrees and additional, less reported cardiomyopathies. The molecular changes associated with the response to Borrelia burgdorferi over the course of infection are poorly understood. Here, we identify broad transcriptomic and proteomic changes in the heart during infection that reveal a profound down-regulation of mitochondrial components. We also describe the long-term functional modulation of macrophages exposed to live bacteria, characterized by an augmented glycolytic output, increased spirochetal binding and internalization, and reduced inflammatory responses. In vitro, glycolysis inhibition reduces the production of tumor necrosis factor (TNF) by memory macrophages, whereas in vivo, it produces the reversion of the memory phenotype, the recovery of tissue mitochondrial components, and decreased inflammation and spirochetal burdens. These results show that B. burgdorferi induces long-term, memory-like responses in macrophages with tissue-wide consequences that are amenable to be manipulated in vivo. ; Supported by grants from the Spanish Ministry of Science, Innovation and Universities (MCIU) co-financed with FEDER funds (SAF2015-65327-R and RTI2018-096494-B-100 to JA; BFU2016-76872-R to EB, AGL2017-86757-R to LA, SAF2017-87301-R to MLMC, SAF2015-64111-R to AP, SAF2015-73549-JIN to HR), Instituto de Salud Carlos III (PIE13/0004 to AP), the Basque Government Department of Health (2015111117 to LA), the Basque Foundation for Innovation and Health Research (BIOEF), through the EiTB Maratoia grant BIO15/CA/016/BS to MLMC, the regional Government of Andalusia co-funded by CEC and FEDER funds (Proyectos de Excelencia P12-CTS-2232) and Fundación Domingo Martínez (to AP). LA is supported by the Ramon y Cajal program (RYC-2013-13666). DB, MMR and TMM are recipients of MCIU FPI fellowships. ACG and AP are recipients of fellowships form the Basque Government. APC is a recipient of a fellowship from the University of the Basque Country. We thank the MCIU for the Severo Ochoa Excellence accreditation (SEV-2016-0644), the Basque Department of Industry, Tourism and Trade (Etortek and Elkartek programs), the Innovation Technology Department of the Bizkaia Province and the CIBERehd network. DB and JA are supported by a grant from the Jesús de Gangoiti Barrera Foundation.