Suchergebnisse

Front Cover -- Advances in Genetics -- ADVANCES IN GENETICS, VOLUME 98 -- ADVANCES IN GENETICS -- Contents -- CONTRIBUTORS -- One - Evolving Centromeres and Kinetochores -- 1. INTRODUCTION -- 2. CENTROMERES: FROM POINT TO HOLO -- 2.1 Fungal Centromeres -- 2.1.1 All the Centromere Diversity in One Kingdom -- 2.2 Plant Centromeres -- 2.2.1 Long and Retro -- 2.3 Animal Centromeres -- 2.4 Holocentrics -- 2.5 Centromere Summary -- 3. KINETOCHORE PROTEINS: SIMILAR YET SO DIVERSE -- 3.1 CENP-A -- 3.1.1 Building the Foundation for the Kinetochore -- 3.2 Inner Kinetochore -- 3.2.1 The Protein Web of Chromosome Segregation -- 3.3 The Outer Kinetochore -- 3.3.1 The Flexible, Load-Bearing Bridge-to-Spindle Microtubules -- 4. FUNGAL OPPORTUNITIES -- 5. SUMMARY AND OUTLOOK -- ACKNOWLEDGMENTS -- REFERENCES -- FURTHER READING -- Two - The Genetics of Parkinson Disease -- 1. TIMELINE OF PARKINSON DISEASE RESEARCH -- 2. ENVIRONMENTAL BASIS OF PARKINSON DISEASE -- 3. GENETIC BASIS OF PARKINSON DISEASE -- 4. AUTOSOMAL DOMINANT PARKINSON DISEASE -- 4.1 Pathogenic Role of SNCA -- 4.2 Pathogenic Role of LRRK2 -- 5. AUTOSOMAL RECESSIVE PARKINSON DISEASE -- 5.1 PRKN -- 5.2 PINK -- 5.3 DJ-1 -- 6. THE PAST AND THE FUTURE OF PARKINSON DISEASE THERAPIES -- 7. CONCLUSIONS -- REFERENCES -- Three - Genetics of Mitochondrial Disease -- 1. INTRODUCTION -- 2. EPIDEMIOLOGY -- 3. OXIDATIVE PHOSPHORYLATION -- 3.1 Structure and Function of the Oxidative Phosphorylation Apparatus, the Electron Transport Chain -- 3.2 Mitochondrial DNA Components of Oxidative Phosphorylation -- 4. MITOCHONDRIAL GENETICS -- 4.1 The Mitochondrial Genome -- 4.2 Mitochondrial DNA Inheritance -- 4.3 Mitochondrial DNA Segregation -- 4.4 Homoplasmy and Heteroplasmy -- 4.5 Transcription -- 4.6 Translation -- 5. MITOCHONDRIAL DNA-ENCODED MITOCHONDRIAL DISORDERS -- 5.1 Rearrangements in Mitochondrial DNA

Advances in genetics have begun to deliver on their promise of new and improved approaches to the prevention and treatment of human disease, including the gene-based therapeutics. The international sports community has begun to recognize the potential harmful use of gene transfer technology by athletes. The task of monitoring and controlling sports doping must be a truly cooperative effort, involving the cooperation of a range of local, national, and international organizations. There are very serious broad social and ethical issues at stake that relate to our definition of sports and its role in our society, as well as the social and ethical principles that are challenged or breached through sport doping, determining which forms of performance enhancement - in sport or any other realm of human activity - are acceptable, and what makes the enhancement of sport performance different from enhancement in other areas of human activity (e.g., cosmetic surgery, mood and learning enhancement through drugs, and drug-based treatment of physical and intellectual changes in normal aging process). This book tackles all these issues and more, serving as the first such focused treatment of this increasingly important topic, which has broad-based implications for science, medicine, sports, and society.