Acetylcholine-responsive cargo release using acetylcholinesterase-capped nanomaterials

Abstract

5785 5788 55 41 ; S ; Godoy-Reyes, TM.; Llopis-Lorente, A.; García-Fernández, A.; Gaviña, P.; Costero, AM.; Martínez-Máñez, R.; Sancenón Galarza, F. (2019). Acetylcholine-responsive cargo release using acetylcholinesterase-capped nanomaterials. Chemical Communications. 55(41):5785-5788. https://doi.org/10.1039/c9cc02602a Díez, P., Esteban-Fernández de Ávila, B., Ramírez-Herrera, D. E., Villalonga, R., & Wang, J. (2017). Biomedical nanomotors: efficient glucose-mediated insulin release. Nanoscale, 9(38), 14307-14311. doi:10.1039/c7nr05535h ; [EN] Mesoporous silica nanoparticles capped with acetylcholinesterase, through boronic ester linkages, selectively release an entrapped cargo in the presence of acetylcholine. The authors acknowledge financial support from the Spanish Government (MAT2015-64139-C4-1-R, MAT2015-64139-C4-4-R and AGL2015-70235-C2-2-R) and the Generalitat Valenciana (PROMETEO2018/024). T. Godoy-Reyes is grateful to Generalitat Valenciana for her Santiago Grisollía fellowship. A. García-Fernández is grateful to the Spanish Government for her FPU fellowship McCorry, L. K. (2007). Physiology of the Autonomic Nervous System. American Journal of Pharmaceutical Education, 71(4), 78. doi:10.5688/aj710478 W. M. Haschek , C. G.Rousseaux and M. A.Wallig , Nervous System , in Fundamentals of Toxicologic Pathology , 2nd edn, Academic Press CY , San Diego , 2010 , p. 377 Klinkenberg, I., Sambeth, A., & Blokland, A. (2011). Acetylcholine and attention. Behavioural Brain Research, 221(2), 430-442. doi:10.1016/j.bbr.2010.11.033 Hasselmo, M. E. (2006). The role of acetylcholine in learning and memory. Current Opinion in Neurobiology, 16(6), 710-715. doi:10.1016/j.conb.2006.09.002 An, M. C., Lin, W., Yang, J., Dominguez, B., Padgett, D., Sugiura, Y., … Lee, K.-F. (2010). Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms. Proceedings of the National Academy of Sciences, 107(23), 10702-10707. doi:10.1073/pnas.1004956107 Ehrenstein, G., Galdzicki, ...