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The relevance of the research is determined by the fact that in the current conditions economic, technological, social, cultural, and religious competition between states becomes increasingly acute. Global threats are constantly increasing which proves the need for international cooperation in this area – right now many countries around the world are working together to reduce the threat of a large-scale epidemic of acute respiratory infection. New challenges of global scale are emerging, and there are still risks of natural, man-made, bio-social, and other catastrophes that could lead to global crisis situations, which requires Russia to strengthen its role in this area. The article is devoted to the problems of selecting prospects for national innovation and technological strategies that allow giving a new impetus to international humanitarian cooperation and emergency humanitarian response. The main aspect of methodological and legal bases of innovative management in international economic cooperation is the implementation of interrelated measures that provide large-scale assistance in areas of major disasters. Materials and publications of domestic and foreign experts working in the humanitarian field were used as sources in this analysis. The main purpose of the research is to substantiate the prospects for innovative management of international cooperation in the humanitarian sphere and in the field of disaster risk reduction. In accordance with the stated purpose of the study, the key tasks of substantiating the organizational foundations for the formation of an integrated system of international emergency humanitarian response, creating a new economic model of innovative management of international cooperation in the humanitarian field in order to increase economic security were solved. The methodological foundations of the research provide for the theory of constructing a new system of economic interstate humanitarian interaction. As a result of the research, the prospective directions of international economic cooperation and humanitarian cooperation, identified on the basis of a specific historical analysis of the development of such interaction, are analyzed. The article analyzes not only theьstages of building an international humanitarian response system with different countries, but also the experience of creating institutional joint organizations in the field of ensuring life safety at the international level. On this basis, a modern economic model of innovative management of international humanitarian aid is proposed, which meets the principles and spirit of international law. Practical recommendations for increasing the importance of the Russian Federation in the international system of emergency humanitarian response are substantiated. We have developed proposals that will allow our country to make a technological breakthrough in the international humanitarian sphere. The results of the research can be applied in the formation and implementation of the national international policy of humanitarian cooperation in the field of life safety.