Ethics and Clinical Neuroinnovation: Fundamentals, Stakeholders, Case Studies, and Emerging Issues

Intro -- Foreword -- Preface -- Contents -- Part I: Foundations of Ethics in Clinical Neuroinnovation -- Chapter 1: The Case for Neuroinnovation: Health Burdens Associated with Psychiatric, Addiction-Related, and Co-occurring Disorders -- The Global Burden of Mental Illness and Addiction -- The Individual Burden of Mental Illness and Addiction -- Progress and the Ongoing Burden -- Relief Through Innovation -- Neuroethics and the Foundation for this Book -- References -- Further Reading -- Chapter 2: Neuroinnovation in Medicine: History and Future -- A Historical Perspective -- A Brief History of Neuroimaging -- Functional Magnetic Resonance Imaging (fMRI) -- Distributed Processing and Functional Specialization -- Key Neuroinnovation: Elucidation of the Human Connectome -- From Neuroinnovation to Neurotherapeutics for Depression -- Depression and Prefrontal Cortex Dysfunction -- Depression and the Subgenual Cingulate Cortex (sgCC) -- Deep Brain Stimulation for Depression -- TMS: A Ground-Breaking, Noninvasive Neuromodulatory Treatment for Depression -- The Story of Targeting: Optimizing Coil Placement -- Accelerated Protocols -- Putting It All Together: Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) -- A Next Big Thing: Focused Ultrasound -- Just Add Nanoparticles -- Closing Thoughts: What Are the Ethical Limits of Neuromodulation? -- References -- Further Reading -- Chapter 3: Clinical Neuroinnovation: Ethical Frameworks and Emerging Issues -- Introduction -- Historical Background to Neuroethics: Principles and Norms -- Assessing Aspects of Clinical Neuroinnovation -- Value (Clinical Need) -- Informed Consent -- Information -- Voluntarism -- Decisional Capacity -- Return of Sensitive Findings -- Novel Ethical Issues in Neuroinnovative Approaches -- Machine Learning -- Brain-Machine Interfaces -- Conclusion -- References.

New ways of understanding the brain - its nature, its capacities, its function, and its dysfunction - hold great promise for human wellbeing. Novel therapeutics spurred by this understanding have important roles addressing many clinical conditions, including Alzheimer Disease, depression, addiction, and obsessive-compulsive disorder. This unique title explores a wide range of groundbreaking sciences and clinical practices for brain-based conditions, including deep brain stimulation, optogenetics, technology-delivered therapies, predictive testing, and new clinical uses of ketamine, cannabis, and other psychoactive substances.An introduction to the imperative to develop new treatments for devastating brain disorders and the state of current therapeutics in psychiatry, addiction, and behavioral disorders is presented, and chapters from leading physician-scientists and neuroethicists outline the clinical and the ethical issues arising in innovation and in the creation of new therapeutics for brain diseases. Written by renowned thought leaders in their fields, the book presents tightly written contributions on novel qualitative and quantitative data from stakeholders in the field, including neuroscientist-clinicians, people living with mental illness and/or addictions, and oversight/policy stakeholders.Concise, anticipatory, and centered on the principles governing human biomedical research and innovation in developing novel therapeutics for brain disorders, Ethics and Clinical Neuroinnovation will be of great value to clinicians, researchers, and students from a vast array of backgrounds, including neuroethics, neuroscience, psychology, psychiatry, philosophy, entrepreneurship, and the law